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Title:	Satisfaction survey with DNA cards method to collect genetic samples for pharmacogenetics studies
Author:	Vidal Taboada, Jose Manuel; Cucala, Mercedes; Mas Herrero, Sergi; Lafuente Fló, Amalia; Cobos Carbó, Alberto
Other authors:	Universitat de Barcelona
Abstract:	Background: Pharmacogenetic studies are essential in understanding the interindividual variability of drug responses. DNA sample collection for genotyping is a critical step in genetic studies. A method using dried blood samples from finger-puncture, collected on DNA-cards, has been described as an alternative to the usual venepuncture technique. The purpose of this study is to evaluate the implementation of the DNA cards method in a multicentre clinical trial, and to assess the degree of investigators' satisfaction and the acceptance of the patients perceived by the investigators.Methods: Blood samples were collected on DNA-cards. The quality and quantity of DNA recovered were analyzed. Investigators were questioned regarding their general interest, previous experience, safety issues, preferences and perceived patient satisfaction. Results: 151 patients' blood samples were collected. Genotyping of GST polymorphisms was achieved in all samples (100%). 28 investigators completed the survey. Investigators perceived patient satisfaction as very good (60.7%) or good (39.3%), without reluctance to finger puncture. Investigators preferred this method, which was considered safer and better than the usual methods. All investigators would recommend using it in future genetic studies. Conclusion: Within the clinical trial setting, the DNA-cards method was very well accepted by investigators and patients (in perception of investigators), and was preferred to conventional methods due to its ease of use and safety.
Subject(s):	DNA analysis Blood Glutathione transferase ADN Sang Farmacogenètica Investigació farmacèutica
Rights:	cc-by, (c) Vidal-Taboada et al., 2006 openAccess http://creativecommons.org/licenses/by/2.0/
Document type:	article
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