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Is the 23-valent pneumococcal polysaccharide vaccine useful in preventing community-acquired pneumonia?
Izquierdo, Conchita; Salleras Sanmartí, Lluís; Domínguez García, Àngela
Universitat de Barcelona
Although bacteremic pneumococcal pneumonia is the most severe form of pneumonia, non-bacteremic forms are much more frequent. Laboratory methods for the diagnosis of nonbacteremic pneumococcal pneumonia have a low sensitivity and specificity, and therefore all-cause pneumonia has been proposed as a suitable outcome to evaluate vaccination effectiveness. This work reviews the epidemiology of community-acquired pneumonia (CAP) and evaluates the effectiveness of the 3-valent pneumococcal polysaccharide vaccine (PPV-23) in preventing CAP requiring hospitalization in people aged ≥65 years. We performed a case-control study in patients aged ≥65 years admitted through the emergency department who presented with clinical signs and symptoms compatible with pneumonia. Weincluded 489 cases and 1,467 controls and it was obtained a vaccine efectiveness of 23.6 (0.9-41.0). Our results suggest that PPV-23 vaccination is effective and reduces hospital admissions due to pneumonia in the elderly, strengthening the rationale for vaccination programmes in this age group.
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32393
2012-10-15
Farmacologia
Pneumònia adquirida a la comunitat
Vacunes
Pharmacology
Community-acquired pneumonia
Vaccines
(c) Transworld Research Network , 2012
Book Part
Transworld Research Network
         

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