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Role of JNK in neurodegenerative diseases
Junyent Herena, Fèlix; Verdaguer Cardona, Ester; Folch López, Jaume; Beas Zárate, Carlos; Pallás i Llibería, Mercè, 1964-; Auladell i Costa, M. Carme; Camins Espuny, Antoni
Universitat de Barcelona
The c-Jun N-terminal kinases (JNK) are members of the MAPK family and can be activated by different stimuli such as cellular stress, heat shock and ultra-violet irradiation. JNKs have different physiological functions and they have been linked to apoptosis in different cell types. Therefore, the JNK signalling pathway is an important target to prevent cell death. In the present chapter, the role of JNKs in neurodegenerative diseases will be discussed, as well as the pharmacological compounds that inhibit this signalling pathway as therapeutic intervention to prevent neuronal death.
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32393
2012-10-15
Farmacologia
Malalties neurodegeneratives
Pharmacology
Neurodegenerative Diseases
(c) Transworld Research Network, 2012
Book Part
Transworld Research Network
         

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