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Calcium alternans produced by increased sarcoplasmic reticulum refractoriness
Rodríguez Cantalapiedra, Inma; Lugo, Carlos; Peñaranda Ayllón, Angelina; Echebarría Domínguez, Blas
Universitat Politècnica de Catalunya. Departament de Física Aplicada
Despite the important role of electro-mechanicalalternans in cardiac arrhythmogenesis, its molecularorigin is not well understood. In this paper we want tostudy alternans that can be associated with alternationsin the cytosolic calcium transient. To this end we studyparticularly, how a malfunction of Ryanodine Receptor(RyR) recovery time from inactivation may induce beatto-beat alternations in intracellular calciumconcentration and how this could affect the stimuluspropagation in inhomogeneous tissue, whose cells exhibitdifferent calcium dynamics.
2012-06-11
Àrees temàtiques de la UPC::Enginyeria dels materials::Biomaterials
Àrees temàtiques de la UPC::Física
Intracellular calcium
Electrocardiography
Restricted access - publisher's policy
Conference Object
IEEE Computer Society Publications
         

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