To access the full text documents, please follow this link:

Activation of Srk1 by the Mitogen-activated Protein Kinase Sty1/Spc1 Precedes Its Dissociation from the Kinase and Signals Its Degradation
López Avilés, Sandra; Lambea Martínez, Eva; Moldón Vara, Alberto; Grande Robles, Maribel; Fajardo, Alba; Rodríguez-Gabriel, Miguel A.; Hidalgo Hernando, Elena; Aligué i Alemany, Rosa Maria
Universitat de Barcelona
Control of cell cycle progression by stress-activated protein kinases (SAPKs) is essential for cell adaptation to extracellular stimuli. The Schizosaccharomyces pombe SAPK Sty1/Spc1 orchestrates general changes in gene expression in response to diverse forms of cytotoxic stress. Here we show that Sty1/Spc1 is bound to its target, the Srk1 kinase, when the signaling pathway is inactive. In response to stress, Sty1/Spc1 phosphorylates Srk1 at threonine 463 of the regulatory domain, inducing both activation of Srk1 kinase, which negatively regulates cell cycle progression by inhibiting Cdc25, and dissociation of Srk1 from the SAPK, which leads to Srk1 degradation by the proteasome.
Proteïnes quinases
Cicle cel·lular
Protein kinases
Cell cycle
cc-by-nc-sa, (c) López-Avilés et al., 2008
Article - Published version
American Society for Cell Biology

Show full item record

Related documents

Other documents of the same author

Jara, Mónica; Vivancos Prellezo, Ana; Calvo, Isabel A.; Moldón, Alberto; Sansó Martínez, Miriam; Hidalgo Hernando, Elena
Bonada i Caparrós, Núria; Prat i Fornells, Narcís; Munné, A.; Rieradevall i Sant, Maria; Alba Tercedor, Javier; Álvarez, M.; Avilés, J.; Casas Grande, Jesús; Jáimez-Cuéllar, P.; Mellado, A.; Moyà, G.; Pardo, I.; Robles, S.; Ramon, G.; Suárez, Ma. Luisa; Toro, M.; Vidal-Abarca Gutiérrez, María Rosario; Vivas, S.; Zamora-Muñoz, C.
Calvo, Isabel A.; Gabrielli, Natalia; Iglesias Baena, Iván; García Santamarina, Sarela; Hoe, Kwang-Lae; Kim, Dong Uk; Sansó Martínez, Miriam; Zuin, Alice; Pérez, Pilar; Ayté del Olmo, José; Hidalgo Hernando, Elena
Hernández, Delia; Altuna, Marta; Cuevas, C.; Aligué i Alemany, Rosa Maria; Albericio Palomera, Fernando; Álvarez Domingo, Mercedes