The aim of this work is to investigate which would be a good preliminary plantwide control structurefor the process of Hydrogen production from bioethanol to be used in a proton exchange membrane(PEM) accounting only steady-state information. The objective is to keep the process under optimal operationpoint, that is doing energy integration to achieve the maximum efficiency. Ethanol, produced fromrenewable feedstocks, feeds a fuel processor investigated for steam reforming, followed by high- and lowtemperatureshift reactors and preferential oxidation, which are coupled to a polymeric fuel cell. Applyingsteady-state simulation techniques and using thermodynamic models the performance of the completesystem with two different control structures have been evaluated for the most typical perturbations. Asensitivity analysis for the key process variables together with the rigorous operability requirements forthe fuel cell are taking into account for defining acceptable plantwide control structure. This is the firstwork showing an alternative control structure applied to this kind of process.