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Dynamic model of the left ventricle for use in simulation of myocardial perfusion SPECT and gated SPECT
Bullich Roig, Santiago; Ros Puig, Domènec; Cot Sanz, Albert; Falcón, C.; Muxí Pradas, África; Pavía Segura, Javier
Universitat de Barcelona
Simulation is a useful tool in cardiac SPECT to assess quantification algorithms. However, simple equation-based models are limited in their ability to simulate realistic heart motion and perfusion. We present a numerical dynamic model of the left ventricle, which allows us to simulate normal and anomalous cardiac cycles, as well as perfusion defects. Bicubic splines were fitted to a number of control points to represent endocardial and epicardial surfaces of the left ventricle. A transformation from each point on the surface to a template of activity was made to represent the myocardial perfusion. Geometry-based and patient-based simulations were performed to illustrate this model. Geometry-based simulations modeled ~1! a normal patient, ~2! a well-perfused patient with abnormal regional function, ~3! an ischaemic patient with abnormal regional function, and ~4! a patient study including tracer kinetics. Patient-based simulation consisted of a left ventricle including a realistic shape and motion obtained from a magnetic resonance study. We conclude that this model has the potential to study the influence of several physical parameters and the left ventricle contraction in myocardial perfusion SPECT and gated-SPECT studies.
Mètode de Montecarlo
Medicina nuclear
Monte Carlo method
Nuclear medicine
(c) The American Association of Physicists in Medicine 2003
Article - Published version
The American Association of Physicists in Medicine

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