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Inhibitors of the M2 channel of influenza A virus
Duque, María D.; Torres, Eva; Valverde, Elena; Barniol, Marta; Guardiola, Salvador; Rey, Matias; Vázquez, Santiago
Universitat de Barcelona
Influenza is a highly contagious, major respiratory tract disease affecting millions of people each year. At present, two classes of antivirals are available: the neuraminidase inhibitors and the M2 proton channel blockers amantadine and rimantadine. However, rapid emergence of M2 blockers resistance makes imperative the development of new anti-influenza drugs. In the last few years several groups have synthesized and evaluated several analogs of amantadine. While several of them are active against wild-type M2 channel only a few are able to inhibit the mutant ion channels that lead to amantadine-resistance.
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32392
2012-01-27
Influenzavirus
Resistència als medicaments
Inhibidors enzimàtics
Influenza viruses
Drug resistance
Enzyme inhibitors
(c) Transworld Research Network, 2011
Book Part
Transworld Research Network
         

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