To access the full text documents, please follow this link: http://hdl.handle.net/2445/21368

Generation of biological association networks: A novel strategy to detect new targets in cancer therapy
Selga i Coma, Elisabet; Almagro García, Ma. Cristina de; Oleaga, Carlota; Mencial, Núria; Ramírez, Sara; Ruiz, F. Xavier; Farrés i Vicén, Jaume; Parés i Casasampera, Xavier; Thibaut, Rémi; Porte Visa, Cinta; Noé Mata, Verónica; Ciudad i Gómez, Carlos Julián
Universitat de Barcelona
The aim of this work was to design a novel strategy to detect new targets for anticancer treatments. The rationale was to build Biological Association Networks from differentially expressed genes in drug-resistant cells to identify important nodes within the Networks. These nodes may represent putative targets to attack in cancer therapy, as a way to destabilize the gene network developed by the resistant cells to escape from the drug pressure. As a model we used cells resistant to methotrexate (MTX), an inhibitor of DHFR. Selected node-genes were analyzed at the transcriptional level and from a genotypic point of view. In colon cancer cells, DHFR, the AKR1 family, PKC¿, S100A4, DKK1, and CAV1 were overexpressed while E-cadherin was lost. In breast cancer cells, the UGT1A family was overexpressed, whereas EEF1A1 was overexpressed in pancreatic cells. Interference RNAs directed against these targets sensitized cells towards MTX.
Podeu consultar el llibre complet a: http://www.trnres.com/ebookcontents.php?id=149
2012-01-27
Càncer
Quimioteràpia
Farmacogenètica
Cancer
Chemotherapy
Pharmacogenetics
(c) Transworld Research Network, 2011
http://hdl.handle.net/2445/32392
Book Part
Transworld Research Network
         

Show full item record

Related documents

Other documents of the same author

Selga i Coma, Elisabet; Oleaga Sancho, Carlota; Ramírez, Sara; Almagro García, Ma. Cristina de; Noé Mata, Verónica; Ciudad i Gómez, Carlos Julián
Selga i Coma, Elisabet; Oleaga Sancho, Carlota; Ramírez, Sara; Almagro García, Ma. Cristina de; Noé Mata, Verónica; Ciudad Gómez, Carles J.
Mencia, Nuria; Selga i Coma, Elisabet; Rico, Isabel; Almagro García, Ma. Cristina de; Villalobos, Xenia; Ramírez, Sara; Adan, Jaume; Hernández, José L.; Noé Mata, Verónica; Ciudad i Gómez, Carlos Julián
Oleaga, Carlota; Ciudad i Gómez, Carlos Julián; Noé Mata, Verónica; Izquierdo Pulido, María Luz
Oleaga, Carlota; Ciudad i Gómez, Carlos Julián; Noé Mata, Verónica; Izquierdo Pulido, María Luz
 

Coordination

 

Supporters