http://www.recercat.cat:80/handle/2072/179325 Wed, 22 May 2013 17:53:42 GMT 2013-05-22T17:53:42Z http://www.recercat.cat:80/bitstream/id/44947/ http://www.recercat.cat:80/handle/2072/179325 http://www.recercat.cat:80/handle/2072/202160 Bicelles: new nano systems for skin applications Barbosa Barros, Lucyanna; Rodriguez, Gelen; Cócera Núñez, Mercedes; Rubio, Laia; Estelrich i Latràs, Joan; Maza Ribera, Alfonso de la; López Serrano, Olga Bicellar systems are lipid nanostructures formed by long- and short-chained phospholipids dispersed in aqueoussolution. Because of their attractive combination of lipid composition, small size and morphological versatility, bicellesbecame new targets for skin research. Bicelles modify the skin biophysical parameters and modulate the skin barrier function acting as enhancers for drug penetration. Moreover, these aggregates have the ability to penetrate through the narrowintercellular spaces of the skin stratum corneum and to reinforce its lipid lamellae. Their structures allows for the incorporation of different molecules that can be carried through the skin layers. Theremarkable versatility of bicelles is their most important characteristic, which makes it possible their use in different fields.These aggregates represent new nanosystems for skin applications. In this work we provide an overview of the main properties ofbicelles and their effects on the skin.; Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32393 http://www.recercat.cat:80/handle/2072/202160 http://www.recercat.cat:80/handle/2072/179527 Molecular simulations of globins: Exploring the relationship between structure, dynamics and function Forti, Flavio; Boechi, Leonardo; Novo de Oliveira, Ana; Bikiel, Damian; Arroyo, Pau; Nadra, Alejandro; Capece, Luciana; Bidon-Chanal Badia, Axel; Martí, Marcelo A.; Estrín, Darío; Luque Garriga, F. Xavier The discovery in the last two decades of novel members of the globin superfamily has challenged the conventional view about the structure and function of globins. Thus, peculiar structural differences are expected to have direct influence on properties related to ligand migration, binding affinity and heme reactivity. Molecular simulations are a valuable tool to gain insigth into the molecular mechanisms that underlie those structural differences, and their relationship with the diversity of functional roles. In this work, the impact of molecular simulations in exploring the linkage between structure, dynamics and function is highlighted for three representative cases: the migration of ligands through the protein matrix of truncated hemoglobins, the modulation of binding affinity by heme distortion in protoglobin, and finally the functional implications due to the equilibrium between penta- and hexacoordination of the heme with distal histidine in neuroglobin.; Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32392 http://www.recercat.cat:80/handle/2072/179527